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Two-stage stochastic programming with robust constraints for the logistics network post-disruption responsestrategy optimization

Frontiers of Engineering Management   Pages 67-81 doi: 10.1007/s42524-022-0240-2

Abstract: To address the LN post-disruption response strategy optimization problem, this study proposes a novelTo enhance the robustness of the response strategy obtained, the conditional value at risk (CVaR) criterionA comparison with the rerouting strategy and two benchmark models demonstrates the superiority of the

Keywords： logistics network design     post-disruption response strategy     two-stage stochastic programming     conditional    

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Durability of neutralizing antibodies and T-cell response post SARS-CoV-2 infection

Yun Tan, Feng Liu, Xiaoguang Xu, Yun Ling, Weijin Huang, Mingquan Guo, Ziyu Fu, Dongguo Liang, Miao Xu, Hongzhou Lu, Saijuan Chen

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 746-751 doi: 10.1007/s11684-020-0822-5

Abstract: after diagnosis and the results were compared to those from cases investigated 2 weeks to 2 months post-infectionNotably, 14 samples available at 6−7 months post-infection all showed significant neutralizing activitiesFurthermore, in 10 blood samples from cases at 6−7 months post-infection used for memory T-cell tests

Keywords： SARS-CoV-2     neutralizing antibodies     T-cell response    

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Modeling of the resilient supply chain system from a perspective of production design changes

Frontiers of Engineering Management   Pages 96-106 doi: 10.1007/s42524-022-0235-z

Abstract: To overcome the impact of insufficient raw material supply on the supply chain in mass disruption scenariosNext, a case study is conducted to demonstrate the PDC strategy and to validate the feasibility and effectivenessThe results show that the restructured RSCS based on the proposed strategy and model can remedy the huge

Keywords： resilient supply chain     supply chain disruption     domain modeling     product design changes    

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Efficacy and safety of JAK inhibitor INC424 in patients with primary and post-polycythemia vera or post-essential

Xin Du,Daobin Zhou

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 437-443 doi: 10.1007/s11684-016-0472-9

Abstract:

A phase II study (A2202) was performed to evaluate the efficacy and safety of JAK inhibitor ruxolitinib in 63 Chinese MF patients. Ruxolitinib was given twice a day (bid) at a starting dose of 15 mg (n=25) or 20 mg (n=38) based on a baseline platelet count. About 94.7% of the patients achieved a reduction in spleen size, 27.0% of which exhibited significant reduction (≥35%) at week 24. Significant improvement in debilitating constitutional symptoms, as assessed by MFSAF v2.0, was observed in patients treated with ruxolitinib. Ruxolitinib treatment was generally well tolerated by Chinese patients. Although the treatment was associated with an increase in certain adverse events (AEs) that were established as identified risks (anemia and thrombocytopenia), these AEs were considered manageable in this clinical setting. Ruxolitinib provided substantial reductions in splenomegaly and improvements in symptoms, and was well-tolerated by Chinese patients with MF.

Keywords： JAK     ruxolitinib     Chinese patients     myelofibrosis    

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Evaluation of endocrine disruption and dioxin-like effects of organic extracts from sewage sludge in

LIU Cao,XU Yiping,MA Mei,HUANG Bingbin,WU Jingdong,MENG Qingyi,WANG Zijian,GEARHEART Robert Alan

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 3,   Pages 433-440 doi: 10.1007/s11783-013-0594-0

Abstract: based on a batch of in vitro bioassays, including a set of recombinant gene yeast assays for endocrine disruption

Keywords： sewage sludge     in vitro bioassay     endocrine disruption     dioxin-like effect    

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Dynamic modelling and simulation of a post-combustion CO capture process for coal-fired power plants

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 2,   Pages 198-209 doi: 10.1007/s11705-021-2057-7

Abstract: Solvent-based post-combustion capture technologies have great potential for CO2 mitigationComposed by a series of partial differential equations, first-principle post-combustion capture modelsfit properties and simplify the chemical and physical process, based on which a universal and hybrid post-combustion

Keywords： CO2 capture     post-combustion capture     simulation     dominant factor    

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Emergency and Response for Cyberspace Security

Yu Quan,Yang Lifeng and Gao Guijun、Kou Ziming、Zhai Lidong

Strategic Study of CAE 2016, Volume 18, Issue 6,   Pages 79-82 doi: 10.15302/J-SSCAE-2016.06.016

Abstract: security in China, this paper proposes that cyberspace security should shift its focus from emergency to response

Keywords： cyberspace security     emergency for cyberspace security     response for cyberspace security     transformationstrategy    

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Adiponectin: mechanisms and new therapeutic approaches for restoring diabetic heart sensitivity to ischemic post-conditioning

Tingting Wang, Shanglong Yao, Zhengyuan Xia, Michael G. Irwin

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 301-305 doi: 10.1007/s11684-013-0283-1

Abstract:

Systemic inflammatory response following myocardial ischemia-reperfusion injury (IRI) to a specificIschemic post-conditioning (IPostC) has emerged as a promising method for myocardial protection against

Keywords： adiponectin     ischemic post-conditioning     ischemia reperfusion injury     diabetes    

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Enhancement of the polynomial functions response surface model for real-time analyzing ozone sensitivity

Jiangbo Jin, Yun Zhu, Jicheng Jang, Shuxiao Wang, Jia Xing, Pen-Chi Chiang, Shaojia Fan, Shicheng Long

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 2, doi: 10.1007/s11783-020-1323-0

Abstract: Abstract • The calculation process and algorithm of response surface model (RSM) were enhanced. • Thenitrogen oxides (NOx) and volatile organic compound (VOC) is a prerequisite for an effective O3 control strategyAn Enhanced polynomial functions Response Surface Model (Epf-RSM) with the capability to analyze O3-NOx-VOCreal time was developed by integrating the hill-climbing adaptive method into the optimized Extended Response

Keywords： Response surface model     Hill-climbing algorithm     Ozone pollution     Precursor emissions     Control strategy    

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Enhanced production of

Shen Huang,Xudong Feng,Chun Li

Frontiers of Chemical Science and Engineering 2015, Volume 9, Issue 4,   Pages 501-510 doi: 10.1007/s11705-015-1544-0

Abstract: However, a low productivity of PGUS and the lack of an effective separation strategy have significantlyA two-stage fermentation strategy was developed where PGUS was first grown with glucose and then PGUSBy using this strategy, the biomass was increased 1.5 times and the PGUS activity increased 5.4 times

Keywords： β-glucuronidase     glycyrrhetic acid monoglucuronide     cell disruption     purification     chromatography    

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Internet of Things (IoT)–blockchain-enabled pharmaceutical supply chain resilience in the post-pandemic

Frontiers of Engineering Management   Pages 82-95 doi: 10.1007/s42524-022-0233-1

Abstract: environment of pharmaceutical supply chain (PSC) has rapidly changed and faced increasing risks of disruptioninvestigate the characteristics of PSC, the key aspects affecting PSC, and the challenges faced by PSC in the post-pandemic

Keywords： pharmaceutical supply chain     Internet of Things     blockchain     resilience     post-pandemic era    

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Manufacturing Power Strategy Path andPreliminary Analysis

Gu Yishana,Zhao Qiang,Liu Dan and Wang Di

Strategic Study of CAE 2015, Volume 17, Issue 7,   Pages 83-82

Abstract:

By comparing and referring the experiences how the four major core elements (first-class indexes) improved manufacturing industry in industrial developed countries. This article analyzed the gap between China and other countries, explored the common regularities how to realize manufacturing power, and estimated the speed and the target to be a strong country in manufacturing industry. This article proposed policy suggestions based on the analysis of 18 secondary-class indexes.

Keywords： manufacturing     manufacturing power     strategic roadmap     industrialization     post-industrialization    

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CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells

Yongping Zhang, Xingying Zhang, Chen Cheng, Wei Mu, Xiaojuan Liu, Na Li, Xiaofei Wei, Xiang Liu, Changqing Xia, Haoyi Wang

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 554-562 doi: 10.1007/s11684-017-0543-6

Abstract:

T cells engineered with chimeric antigen receptor (CAR) have been successfully applied to treat advanced refractory B cell malignancy. However, many challenges remain in extending its application toward the treatment of solid tumors. The immunosuppressive nature of tumor microenvironment is considered one of the key factors limiting CAR-T efficacy. One negative regulator of T cell activity is lymphocyte activation gene-3 (LAG-3). We successfully generated LAG-3 knockout T and CAR-T cells with high efficiency using CRISPR-Cas9 mediated gene editing and found that the viability and immune phenotype were not dramatically changed during in vitro culture. LAG-3 knockout CAR-T cells displayed robust antigen-specific antitumor activity in cell culture and in murine xenograft model, which is comparable to standard CAR-T cells. Our study demonstrates an efficient approach to silence immune checkpoint in CAR-T cells via gene editing.

Keywords： CAR-T     CRISPR-Cas9     LAG-3    

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Development Strategy of Smart Emergency-Response Technology for Disasters and Accidents by 2035

Liu Yi, Zhang Yudong, Zhang Hui, Fan Weicheng

Strategic Study of CAE 2021, Volume 23, Issue 4,   Pages 117-125 doi: 10.15302/J-SSCAE-2021.04.014

Abstract:

The development of smart emergency-response technology for natural disastersThis study aims to clarify the long-term goals for smart emergency-response technology development byand provide support for the systematic planning and forward-looking deployment of a smart emergency-responsestrategy in China.this study analyzes the international situation and main development trends of the smart emergency-response

Keywords： natural disaster，accident，smart emergency-response technology，information technology enabling    

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Parametric study of hexagonal castellated beams in post-tensioned self-centering steel connections

Hassan ABEDI SARVESTANI

Frontiers of Structural and Civil Engineering 2019, Volume 13, Issue 5,   Pages 1020-1035 doi: 10.1007/s11709-019-0534-6

Abstract: The effects of important parameters (beam reinforcing plates, initial post-tensioning, and material propertiesof steel angles) on the behavior of hexagonal castellated beams in post-tensioned self-centering (PTSCThe web-post buckling in hexagonal castellated beams has been identified as the dominant failure modewhen excessive initial post-tensioning force is applied to reach greater bending moment resistance,so it is required to limit the highest initial post-tensioning force to prevent this failure.

Keywords： finite element analysis     hexagonal castellated beam     parametric study     post-tensioned self-centering steel    

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Title Author Date Type Operation

Two-stage stochastic programming with robust constraints for the logistics network post-disruption responsestrategy optimization

Journal Article

Durability of neutralizing antibodies and T-cell response post SARS-CoV-2 infection

Yun Tan, Feng Liu, Xiaoguang Xu, Yun Ling, Weijin Huang, Mingquan Guo, Ziyu Fu, Dongguo Liang, Miao Xu, Hongzhou Lu, Saijuan Chen

Journal Article

Modeling of the resilient supply chain system from a perspective of production design changes

Journal Article

Efficacy and safety of JAK inhibitor INC424 in patients with primary and post-polycythemia vera or post-essential

Xin Du,Daobin Zhou

Journal Article

Evaluation of endocrine disruption and dioxin-like effects of organic extracts from sewage sludge in

LIU Cao,XU Yiping,MA Mei,HUANG Bingbin,WU Jingdong,MENG Qingyi,WANG Zijian,GEARHEART Robert Alan

Journal Article

Dynamic modelling and simulation of a post-combustion CO capture process for coal-fired power plants

Journal Article

Emergency and Response for Cyberspace Security

Yu Quan,Yang Lifeng and Gao Guijun、Kou Ziming、Zhai Lidong

Journal Article

Adiponectin: mechanisms and new therapeutic approaches for restoring diabetic heart sensitivity to ischemic post-conditioning

Tingting Wang, Shanglong Yao, Zhengyuan Xia, Michael G. Irwin

Journal Article

Enhancement of the polynomial functions response surface model for real-time analyzing ozone sensitivity

Jiangbo Jin, Yun Zhu, Jicheng Jang, Shuxiao Wang, Jia Xing, Pen-Chi Chiang, Shaojia Fan, Shicheng Long

Journal Article

Enhanced production of

Shen Huang,Xudong Feng,Chun Li

Journal Article

Internet of Things (IoT)–blockchain-enabled pharmaceutical supply chain resilience in the post-pandemic

Journal Article

Manufacturing Power Strategy Path andPreliminary Analysis

Gu Yishana,Zhao Qiang,Liu Dan and Wang Di

Journal Article

CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells

Yongping Zhang, Xingying Zhang, Chen Cheng, Wei Mu, Xiaojuan Liu, Na Li, Xiaofei Wei, Xiang Liu, Changqing Xia, Haoyi Wang

Journal Article

Development Strategy of Smart Emergency-Response Technology for Disasters and Accidents by 2035

Liu Yi, Zhang Yudong, Zhang Hui, Fan Weicheng

Journal Article

Parametric study of hexagonal castellated beams in post-tensioned self-centering steel connections

Hassan ABEDI SARVESTANI

Journal Article